Mirjana Lulic-Botica, PharmD

Mirjana Lulic-Botica, PharmD

Instructor (Clinical)

Hutzel Women's Hospital, 3990 John R Street, Detroit MI 48201

Office hours

By appointment

Mirjana Lulic-Botica, PharmD

Bio Sketch

Dr. Lulic-Botica is a clinical pharmacist working at Hutzel Women's Hospital in the Detroit Medical Center, where she has been the neonatal clinical pharmacy specialist for 22 years, responsible for providing pharmaceutical care to the neonatal intensive care and step down unit. Dr. Lulic-Botica's clinical responsibilities include providing safe, accurate and prompt care as it relates to drug therapy in vulnerable populations. Her areas of research have been directed toward clinical pharmacology, and she has published work regarding therapeutic drug monitoring of caffeine in collaboration with her mentor, Dr. J. Aranda. Additionally  Dr. Lulic-Botica has been the pharmacist of record (PoR) for multiple research studies at Hutzel Women’s Hospital involving research protocols in obstetrics and gynecology, neonatology, and Division of AIDS sponsored clinical research. She is currently the PoR of two active neonatal research protocols. She is board certified pharmaceutical specialist and a member of the American Pharmaceutical Association, Pediatric Pharmacy Advocacy Group, and the American College of Clinical Pharmacology.


  • PharmD, Idaho State University, 2015
  • B.S., Wayne State University, 1994
  • B.S., Wayne State University, 1991

Research Interests

  • Neonatal nutrition
  • Pharmacokinetics of common antimicrobial agents
  • Neonatal pain and sedation
  • Neonatal abstinence syndrome

Clinical Area(s) of Expertise

  • Neonatal clinical pharmacy
  • Neonatal pharmacology
    • Reducing infection
    • Medication safety
    • Antimicrobial stewardship
    • Improving vaccine rates
    • Care transitions
    • Neonatal nutrition optimization
    • Neonatal pharmacokinetics

Selected publications

  • Lehr Vt, Lulic-Botica M, Lindblad WJ, Kazzi NJ, Aranda JV. Management of infiltration in neonates using duoderm hydroactive gel. Am J Perinatal. 2004; Oct;21(7):409-414.
  • Frattarelli Da, Ergun H, Lulic-Botica M, Lehr VT, Aranda JV, Vancomycin elimination in human infants with intrauterine growth retardation. Pediatr Infect DIs J 2005;Nov;24(11):979-983.
  • Natarajan G, Lulic-Botica M, Rongkavilit C, Pappas A. Experience with caspofungin in the treatment of persistent fungemia in neonates. J Perinatol. 2005 Dec;25(12):770-777.
  • Nataraja G, Lulic-Botica M, Aranda JVA, Clinical Pharmacology of Caffeine in the Newborn. NeoReviews 2007 May Vol8No5:E1-E7.
  • Natarajan G, Lulic-Botica M, Thomas R, Aranda JVA. Therapeutic Drug Monitoring for Caffeine in Preterm Neoantes; An Unnecessary Exercise? Pediatrics 2007 May;119(5): 936-940
  • Sood BG, Lulic-Botica M, Holzhausen KA, Pruder S, Kellogg H, Salari V, Thomas R. The risk of necrotizing enterocolitis after indomethacin tocolysis. Pediatrics. 2011 Jul;128(1):e54-62.
  • Martin A, Pappas A, Lulic-Botica M, Natarajan G. Impact of 'targeted' fluconazole prophylaxis for preterm neonates: efficacy of a highly selective approach? J Perinatol. 2012 Jan;32(1):21-6
  • Lulic-Botica M, Dejesus L. Colistin Therapy in a 23-Week Gestational-Age Neonate with Multidrug-Resistant Acinetobacter baumannii Pneumonia. AJP Rep. 2011 Sep;1(1):7-10.
  • Lulic-Botica M, Rajpurkar M, Sabo C, Tutag-Lehr V, Natarajan G. Fluctuations of anti-Xa concentrations during maintenance enoxaparin therapy for neonatal thrombosis. Acta Paediatr. 2012 Apr;1014.
  • Bajaj M, Lulic-Botica M, Natarajan G. Evaluation of cerebrospinal fluid parameters in preterm infants with intraventricular reservoirs. J Perinatol. 2012 Oct;32(10):786-90.
  • Du W, Lehr VT, Lieh-Lai M, Koo W, Ward RM, Rieder MJ, Van Den Anker JN, Reeves JH, Mathew M, Lulic-Botica M, Aranda JV. An algorithm to detect adverse drug reactions in the neonatal intensive care unit. J Clin Pharmacol. 2013 Jan;53(1):87-95.
  • Lulic-Botica M, Scheer T, Edward D, Thomas RL, Natarajan G. Impact of small-for-gestational age (SGA) status on gentamicin pharmacokinetics in neonates. J Clin Pharmacol. 2014 Jan;54(1):39-45.
  • Natarajan G, Monday L, Scheer T, Lulic-Botica M. Timely empiric antimicrobials are associated with faster microbiologic clearance in preterm neonates with late-onset bloodstream infections. Acta Paediatr. 2014 Oct;103(10):e418-23.
  • Sood BG, Keszler M, Garg M, Klein JM, Ohls R, Ambalavanan N, Cotten CM, Malian M, Sanchez PJ, Lakshminrusimha S, Nelin LD, Van Meurs KP, Bara R, Saha S, Das A, Wallace D, Higgins RD, Shankaran S; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Researchh Network.. Inhaled PGE1 in neonates with hypoxemic respiratory failure: two pilot feasibilitytrials. 2014 Dec 12;15:486. (Pharmacist of record)
  • Ravichandran S, Chouthai NS, Patel B, Sharma A, Gupte A, Ma MM, Mamilla D, Lulic-Botica M, Thomas R, Kamat D. Higher daily doses of caffeine lowered the incidence of moderate to severe neurodevelopmental disabilities in very low birth weight infants. Acta Paediatr. 2019 Mar;108(3):430-435. doi: 10.1111/apa.14465. Epub 2018 Jul 19.
  • Bajaj M, Lulic-Botica M, Hanson A, Natarajan G. Feeding during transfusion and the risk of necrotizing enterocolitis in preterm infants. J Perinatol. 2019 Apr;39(4):540-546. doi: 10.1038/s41372-019-0328-7. Epub 2019 Feb 5.
  • El-Fadeel H, Velumula P, Lulic-Botica M, Natarajan G, Thomas R, Botica G, Bajaj M. Effect of an exclusive human milk diet on feeding tolerance in preterm infants. J Perinatol. 2022 Feb 18. doi: 10.1038/s41372-022-01348-y. Epub ahead of print. PMID: 35184144
  • Velumula PK, Elbakoush F, Tabb C 2nd, Farooqi A, Lulic-Botica M, Jani S, Natarajan G, Bajaj M. Breast milk vs 24% sucrose for procedural pain relief in preterm neonates: a non-inferiority randomized controlled trial. . J Perinatol. 2022 Jul;42(7):914-919. doi: 10.1038/s41372-022-01352-2. Epub 2022 Feb 23. PMID: 35197549

Current Research

  • Maternal transfer of gentamicin and neonatal implications

Courses taught by Mirjana Lulic-Botica, PharmD

Winter Term 2024

Winter Term 2023

Winter Term 2022

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